Applications of DNA tetrahedron nanostructure in cancer diagnosis and anticancer drugs delivery

Abstract DNA nanostructures constructed under the guidance of nanotechnology have developed rapidly for last two decades, standing at forefront in biomedical field. Among them, tetrahedron nanostructure (DTN) has emerged as one most representative nanostructures. DTN was easily formed by one-step annealing four single-stranded DNA. Due to its unique advantages such simple and stable structural composition, high synthesis efficiency, uniform nanometer size, programmability, good biocompatibility, been widely used biological detection, imaging, drug delivery, other fields, shows a great potential. Especially detection cancer-related biomarkers delivery anticancer drugs, nano-platforms based on achieved success. In this review, we focus applications cancer diagnosis therapy, well challenges prospects.